Endocrinology Medical News about thyroid tumors;uncertain malignant potential

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. AHA Guidelines on Cardiac CT for Assessing Coronary Artery Disease

3. Rapid correction of low vitamin D status in nursing home residents

4. 2008 Exclusive Survey—Earnings: Good news for primary care income

5. Medicare pay-for-reporting effort draws fire from frustrated doctors

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Thyroid tumours of uncertain malignant potential: frequency and diagnostic reproducibility
Virchows Archiv, 06/24/09

Hofman V et al. - In a trial to investigate the frequency of thyroid tumours of uncertain malignant potential (TT-UMP) diagnosed in a single institution, observer variation among 4 pathologists, and whether immunohistochemical and molecular genetic profiling of TT-UMP provide additional information concerning such lesions, it was found that the frequency of TT-UMP is low in the institution. Diagnostic reproducibility is within the same range as other published data on follicular-patterned thyroid tumours. The ancillary methods have a low impact on aiding diagnosis of such lesions.

Methods

A series of 31 diagnosed TT-UMP (2.9%) out of 1078 consecutive thyroidectomies were analysed.

Results

It comprised 15 follicular thyroid tumours of UMP (FT-UMP) and 16 well-differentiated tumours of UMP (WDT-UMP).
Observer concordance was 70% for all TT-UMP.
>50% of FT-UMP expressed galectin-3 and CK19, whereas >50% of WDT-UMP expressed HBME-1.
5 cases of TT-UMP showed N-RAS mutations, while 1 showed H-RAS mutation and another PAX8/PPARγ rearrangement.

<< Previous
Treatment thresholds for osteoporosis in men on androgen...

Next >>
How Many Calories Are on Our Plate? Expected Fullness, Not...