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The efficacy of omega-3 fatty acid supplementation on plasma homocysteine and malondialdehyde levels of type 2 diabetic patients
Nutrition, Metabolism & Cardiovascular Diseases, 06/24/09
Pooya S et al. – Consumption of omega-3 fatty acid supplements (3 g/day) for 2 mo decreases levels of homocysteine in diabetic pts with no change in fasting blood sugar (FBS), malondialdehyde (MDA), and C-reactive protein (CRP) levels.
Methods- Study of the effect of omega-3 fatty acids on concentration of homocysteine and MDA in diabetic pts
- Randomized double-blind, placebo-controlled clinical trial on 81 pts with type 2 diabetes
- Randomization to either treatment or control groups
- Administration of 3 capsules of omega-3 fatty acids or placebo daily for 2 mo
- Similar body mass index and food intake for both groups
- Determination at study start and after 2 mo of supplementation levels of HbA1c, homocysteine, MDA, CRP, total cholesterol, LDL-cholesterol and FBS
- Due to omega-3 fatty acid supplementation, homocysteine changed significantly in both treatment and control groups
- HbA1c decreased by 0.75% in treatment group and increased by 0.26% in control group
- Changes in FBS, MDA, CRP, total cholesterol, and LDL-cholesterol levels not significant
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