Endocrinology

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Thirst perception and AVP production in a kindred with an activating mutation of the type 2 Vasopressin receptor. The pathophysiology of Nephrogenic Syndrome of Antidiuresis (NSIAD)
European Journal of Endocrinology, 06/29/09

Cheetham T et al. - The authors conclude that female carriers of activating mutations of the vasopressin receptor (V2R) are susceptible to hyponatraemia and therefore need to be provided with advice regarding fluid intake. An altered thirst perception may increase susceptibility to hyponatraemia. The presence of measurable amounts of AVP in patients with hyponatraemia does not exclude the diagnosis of NSIAD.

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