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Circulating FGF21 is induced by PPAR agonists but not ketosis in Man
Journal of Clinical Endocrinology and Metabolism, 06/17/09
Christodoulides C et al. - FGF21 does not play a major role in regulating the fasting response or ketosis in man. However, plasma FGF21 is elevated in response to pharmacological activation of PPAR-alpha and PPAR-delta and may contribute to the beneficial metabolic effects observed in response to pharmacotherapy with these compounds.
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