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See Latest ArticlesIs body mass index before middle age related to coronary heart disease risk in later life? Evidence from observational studies
International Journal of Obesity, 06/19/09
Owen CG et al. – Body mass index (BMI) is positively related to coronary heart disease (CHD) risk from childhood onwards; the associations in young adults are consistent with those observed in middle age pts. Long-term control of BMI from childhood may be important to reduce the risk of CHD.
Methods- Study of the relationship of BMI before age 30 yrs to CHD risk in later life
- Systematic review of published studies relating BMI between age 2-30 yrs to later CHD risk
- Search of Medline (1950+), Embase (1980+) and Web of Science (1970_) databases (to November 2007)
- Independent extraction by 2 authors of relative risks (RR) of CHD associated with 1 standard deviation (SD) higher BMI (most based on a narrow age range at measurement)
- Combination by random-effect models
- Of 15 studies, 17 estimates (731,337 pts, 23 894 CHD events) of association of early BMI to later CHD outcome
- BMI in early childhood (2–6 yrs, 3 estimates) showed weak inverse association with CHD risk (RR 0.94)
- BMI in later childhood (7 to <18 yrs, 7 estimates) and BMI in early adult life (18–30 yrs, 7 estimates) both positively related to later CHD risk (RR 1.09; RR 1.19)
- Considerable statistical heterogeneity between study estimates
- Results unaffected by adjustment for social class and/or cigarette smoking, blood pressure and/or total cholesterol, in studies with available data
- Gender and year of birth (1900–1976) had little effect on association
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