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Overweight in midlife and risk of dementia: A 40-year follow-up study
International Journal of Obesity, 06/19/09

Hassin LB et al. – Findings support increased risk for later dementia in midlife overweight pts. The risk is increased for both Alzheimer's disease and vascular dementia, with same pattern for men and women.

Methods

Study of whether overweight status in midlife increases dementia risk later in life
Assessment of body mass index in 1152 Swedish Twin Registry subjects age 45–65 yrs in 1963
Pts later screened for dementia in prospective study with up to 40-yr follow-up
Dementia diagnosis for 312 pts
Logistic regression analyses adjusted for demographic factors, smoking/alcohol habits

Results

On adjusted analyses men and women categorized as overweight in midlife had elevated risk of dementia, Alzheimer's disease, and vascular dementia
Further adjustments for diabetes and vascular diseases did not substantially affect associations, except for vascular dementia, reflecting significance of diabetes and vascular diseases in etiology of vascular dementia
No significant interaction between overweight and APOE alt epsilon4 status, indicating that having both risk factors does not have a multiplicative effect with regard to dementia risk

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