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Wang Y et al. - The findings show that GDF-9 regulates the expression of R-Smad2/3-responsive reporter genes through ALK4, 5 or 7 in extra-ovarian (adrenocortical and Sertoli) cells with similar potency and signalling pathway to its actions on granulosa cells, but suggest that expression of BMPRII, ALK5 and R-Smads 2 and 3 may not be sufficient for a cell to respond to GDF-9.

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