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Lack of effect of IGF-I on the glomerular filtration rate in non-diabetic patients with advanced chronic kidney disease
Growth Hormone & IGF Research, 06/10/09
Kuan Y et al. - Although intermittent rhIGF-I therapy elevated serum total IGF-I and prevented any fall in serum IGFBP-3, it failed to increase GFR in non-diabetic patients with advanced CKD. The lack of efficacy was attributed to the presence of renal IGF-I resistance in CKD.
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