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Hindmarsh PC et al. - The starting dose should be 150 mug/m2/day, and the dose thereafter titrated to plasma renin activity and blood pressure. Despite adequate glucocorticoid substitution and concordance with medical therapy, control can be difficult during puberty due to alterations in the clearance of hydrocortisone, and dosing schedules may need to be adjusted to account for this.

Today in Adrenal Glands...keeping you current

High-Calorie Glucose-Rich Food Attenuates Neuroglycopenic Symptoms in Patients with Addison's Disease
Journal of Clinical Endocrinology and Metabolism, 12/11/09

Association of the CYP27B1 C(-1260)A Polymorphism with Autoimmune Addison's Disease
Experimental and Clinical Endocrinology & Diabetes, 12/10/09

Effectiveness of cabergoline in monotherapy and combined with ketoconazole in the management of Cushing's disease
Pituitary, 12/08/09

Today in Pharmacology/kinetics...keeping you current

Treatment with alpha-lipoic acid reduces asymmetric dimethylarginine in patients with type 2 diabetes mellitus
Translational Research, The Journal of Laboratory and Clinical Medicine, 12/11/09

Insulin therapy in type 2 diabetes: insulin analogue mix 50, a potential role in reducing postprandial hyperglycaemia and cardiovascular disease
Expert Opinion in Pharmacotherapy, 12/11/09

Effect of Raloxifene on Serum Lipids for Type 2 Diabetic Menopausal Women with or without Statin Treatment
Medical Principles and Practice, 12/11/09