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Oral glucose tolerance test in Italian overweight/obese children and adolescents results in a very high prevalence of impaired fasting glycaemia, but not of diabetes
Diabetes/Metabolism Research and Reviews, 06/05/09
Cambuli VM et al. - In children, the prevalence of IFG is higher than that reported in other European cohorts, whereas T2D is rare. IFG appears not useful to detect IGT in childhood. Paediatric diagnostic cut-points, glucose load and timing of sampling need to be further validated to define glucose abnormalities in obese children that, compared with normal weight subjects, already are characterised by a different metabolic phenotype.
Marco G. Baroni, 06/06/09
| This is an observational study conducted on a large cohort of Italian children and adolescents (535 overweight/obese and 201 normal weight children). The study aimed to establish prevalence and clinical characteristics of impaired glucose regulation (IFG, IGT, DM) in these children. Also the predictive value of IFG to identify IGT and DM was evaluated. The study showed that in these obese children IFG was more prevalent (2-3 times) than previously reported in other European populations. However, IFG appears not useful to detect IGT or DM in childhood and this observation questions the use of the OGTT based on adult parameters to investigate paediatric hyperglycemia. |
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