Endocrinology

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The p38 MAPK regulates 11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2) expression in human trophoblast cells through modulation of 11-beta-HSD2 mRNA stability
Endocrinology, 06/10/09

Sharma A et al. - The findings suggest a novel pathway controlling placental 11-beta-HSD2 expression resulting from the activation of p38 MAPK. Given that p38-alpha is abundantly expressed in the human placenta where its function is largely unknown, the present study also reveals 11-beta-HSD2 as an important target through which p38-alpha may regulate human placental function, and consequently fetal growth and development.

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