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See Latest ArticlesHistone Acetylated Control of Fibroblast Growth Factor Receptor 2 Intron 2 Polymorphisms and Isoform Splicing in Breast Cancer
Molecular Endocrinology, 06/05/09
Zhu X et al. - The findings highlight the potential role of histone acetylation in modulating access to selected polymorphic sites within intron 2 as well as downstream splicing sites in generating variable FGFR2 levels and isoforms in breast cancer.
Shereen Ezzat, 06/05/09
| Single nucleotide polymorphisms are of increasingly recognized significance. How they impact endogenous gene expression and function, however, remains largely unknown. In this study, we demonstrate that intronic polymorphisms associated with increased breast cancer risk alter DNA accessibility to promote transcription factor binding. Such interactions serve to modulate gene expression beyond the role of classical promoters. |
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Today in Basic Science/Genetics...keeping you current
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Prevalence of Pancreatic Diabetes in Patients Carrying Mutations or Polymorphisms of the PRSS1 Gene in the Han Population
Diabetes Technology & Therapeutics, 12/17/09
New Mutations in the RET Protooncogene-L881V - Associated with Medullary Thyroid Carcinoma and -R770Q - in a Patient with Mixed Medullar/Follicular Thyroid Tumour
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Today in Reproductive Endocrinology...keeping you current
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A new FSHbeta mutation in a 29 year-old woman with primary amenorrhea and isolated FSH deficiency: functional characterization and ovarian response to human recombinant FSH
European Journal of Endocrinology, 12/17/09
Associations of Birthweight and Gestational Age with Reproductive and Metabolic Phenotypes in Women with Polycystic Ovarian Syndrome and Their First-Degree Relatives
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