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Apolipoprotein B but not low-density lipoprotein cholesterol is associated with coronary artery calcification in type 2 diabetic Caucasians
Diabetes, 06/15/09

Martin SS et al. – Plasma apolipoprotein B (apoB), but not LDL-cholesterol (LDL-C), levels were associated with coronary artery calcification (CAC) scores in type 2 diabetic Caucasians. ApoB levels may be particularly useful in assessing atherosclerotic burden and cardiovascular risk in type 2 diabetes.

Methods

Study of apoB is a superior marker of CAC relative to LDL-C
Cross-sectional analyses of Caucasian subjects in 2 community-based studies
Penn Diabetes Heart Study [(PDHS): 611 type 2 diabetic subjects; 71.4% men
Study of Inherited Risk of Coronary Atherosclerosis [(SIRCA): 803 non-diabetic subjects, 52.8% men
Multivariate analysis of apoB and LDL-C stratified by diabetes status

Results

In type 2 diabetes, CAC associated with apoB but not LDL-C after adjusting for age, gender, and medication
In non-diabetic subjects, both LDL-C and apoB associated with CAC
In combined analysis of diabetic and non-diabetic subjects, apoB provided value in predicting CAC scores beyond LDL-C, total cholesterol, the total cholesterol/HDL-C and triglyceride/HDL-C ratios, and marginally beyond non-HDL-C

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