Endocrinology Medical News about cardiovascular risk factors;late-onset autosomal diabetes;HNF1A gene variants

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HNF1A gene variants and cardiovascular risk factors in individuals with late-onset autosomal dominant diabetes: A cross-sectional study
Cardiovascular Diabetology, 06/05/09

Giuffrida FMA et al. – Late onset autosomal dominant diabetes mellitus (LOADDM) is clinically indistinguishable from classic type 2 diabetes mellitus ((CT2DM). However, LOADDM group is enriched for common HNF1A polymorphisms A98V and S487N. I27L showed "protective effect" on hypertriglyceridemia, suggesting a role for HNF1A on the diabetic pt lipid profile. These data contribute to the understanding of the complex interactions between genes, hyperglycemia and cardiovascular risk factors development in T2DM.

Methods

Study of the relationship of HNF1A SNPs with cardiovascular risk factors in LOADDM and characterization in contrast to CT2DM
Assessment of 18 LOADDM pts (age at onset > 40 yrs; diabetes in 3 contiguous generations, uniparental lineage) with 48 CT2DM pts and 42 normoglycemic controls (N group)

Results

LOADDM showed significantly higher frequencies of SNPs A98V and S487N of HNF1A vs CT2DM
I27L did not show significant difference but associated with lower risk of hypertriglyceridemia
Protective effect" independent from other well-known predictive risk factors for hypertriglyceridemia, such as waist circumference and HDL on logistic regression

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