Endocrinology Medical News about adiponectin gene variants;metabolic syndrome;primary aldosteronism;essential hypertension

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Metabolic syndrome in primary aldosteronism and essential hypertension: Relationship to adiponectin gene variants
Nutrition, Metabolism & Cardiovascular Diseases, 06/05/09

Ronconi V et al. – Data confirm a higher prevalence of metabolic syndrome among pts with primary aldosteronism (PA) vs matched essential hypertensive (EH) pts. Genetic analysis of T45G and G276T adiponectin gene polymorphisms showed that, genotypes 45G/G+G/T have a protective role on metabolic complications, but the genotype 276T/T defined PA and EH pts with a worse metabolic profile.

Methods

Study of whether metabolic syndrome represents a common feature in PA pts vs EH pts
Study of the impact of 2 common adiponectin gene variants on parameters of metabolic syndrome
Metabolic syndrome defined by ATPIII criteria
Subjects: 89 PA pts; 164 matched EH pts

Results

Detection of 2 adiponectin gene single nucleotide polymorphisms, T45G and G276T, in all PA pts and in 135 EH pts
PA pts had higher prevalence of metabolic syndrome vs EH pts (45% vs 30)
In PA pts, genotypes 45T/G+G/G associated with significantly lower values of waist circumference, HOMA-IR and serum aldosterone
In both PA pts and EH pts, 276T/T genotype associated with significantly worse metabolic profile and a higher risk for the metabolic syndrome

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