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See Latest ArticlesEstradiol-17-beta inhibits GnRH-induced Ca2+ in gonadotropes to regulate negative feedback on LH release
Endocrinology, 06/05/09
Iqbal J et al. - Inhibition of the GnRH-induced increase in [Ca2+]i in gonadotropes by E2 is a likely mechanism for the negative feedback effect of E2 on LH secretion involving a rapid non-genomic effect of E2. Activation of the MAPK pathway by E2 may be the mechanism for the time-delayed positive feedback effect on LH secretion at the level of the gonadotrope.
Today in Basic Science/Genetics...keeping you current
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Dual promoter regulation of death-associated protein kinase gene leads to differentially silenced transcripts by methylation in cancer
Carcinogenesis, 12/15/09
HIF-1 is induced via EGFR activation and mediates resistance to anoikis-like cell death under lipid rafts/caveolae-disrupting stress
Carcinogenesis, 12/15/09
Gene expression of PPARgamma and PGC-1alpha in human omental and subcutaneousadipose tissue is related to insulin resistance markers and mediates beneficial effects of physical training
European Journal of Endocrinology, 12/15/09
Today in Reproductive Endocrinology...keeping you current
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Defining hyperandrogenism in polycystic ovary syndrome: measurement of testosterone and androstenedione by liquid chromatography-tandem mass spectrometry and analysis by receiver operator characteristic (ROC) plots
European Journal of Endocrinology, 12/15/09
A new FSHbeta mutation in a 29 year-old woman with primary amenorrhea and isolated FSH deficiency: functional characterization and ovarian response to human recombinant FSH
European Journal of Endocrinology, 12/15/09
Hypogonadism in females with Prader-Willi syndrome from infancy to adulthood: variable combinations of a primary gonadal defect and hypothalamic dysfunction
European Journal of Endocrinology, 12/15/09
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