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Prenatally-induced changes in muscle structure and metabolic function facilitate exercise-induced obesity prevention
Endocrinology, 06/05/09

Huber K et al. - Exercise-induced lactate accumulation was effectively prevented by stimulation of a lactate shuttle, driven by the increases in MCT4 and MCT1 in white muscle. This enhanced metabolic flexibility in IUGR offspring may facilitate muscle contractile performance, and therefore support moderate daily exercise for effective obesity prevention.

Exclusive Author Commentary
Korinna Huber, 07/08/09

In spite of enormous investments in public health strategies to combat obesity development, many strategies have not been successful, and the societal and economic impact of metabolic disorders continues to increase at an alarming rate. Our studies have identified different mechanistic pathways to obesity and highlight the health benefits of metabolic flexibility for obesity prevention. Further research is required to develop tailored prevention strategies that improve long-term health. For more information please contact: Prof Korinna Huber (Korinna.Huber@tiho-hannover.de) or Prof Bernhard Breier (B.Breier@massey.ac.nz).

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