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Cavalieri L et al. - Data from large clinical studies have shown that CCAs are not associated with the undesirable metabolic effects seen with older agents such as thiazide diuretics and [beta]-adrenoceptor antagonists that are used to treat hypertension. Indeed, reductions in cardiovascular risk and rates of onset of new cases of diabetes mellitus have been reported in trials in patients with hypertension treated with CCAs. These beneficial effects extend beyond those expected to accompany reductions in BP.


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