Endocrinology

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Gemcitabine and oxaliplatin combination chemotherapy for metastatic well-differentiated neuroendocrine carcinomas
Cancer, 06/01/09

Cassier PA et al. – Gemcitabine-oxaliplatin combination (GEMOX) is active and well tolerated in pretreated pts with metastatic neuroendocrine tumors.

• Study of GEMOX efficacy in treatment of pts with metastatic neuroendocrine tumors
• GEMOX treatment for 20 consecutive pts with progressive disease, most cases after failure of other chemotherapy regimens (median 2 regimens)
• Follow-up for evidence of toxicity, response, and survival
• Exclusion from efficacy analysis of 2 pts chemotherapy-naive at treatment initiation

• Toxicity manageable overall
• Treatment discontinuation due to oxaliplatin-induced neurotoxicity (grade 2) in 6 pts (30%)
• Partial response for 3 (17%) of 18 pts
• Median progression-free survival: 7 mo
• Median overall survival: 23.4 mo

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