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Limited Value of Adrenal Biopsy in the Evaluation of Adrenal Neoplasm
Archives of Surgery, 05/19/09

Mazzaglia PJ et al. - Biopsy is unhelpful in patients with isolated adrenal incidentaloma. Despite atypical radiographic findings, all nonfunctioning nodules 5 cm or less were benign. The negative predictive value is unacceptably low and cannot be relied on to rule out malignancy. The value of biopsy remains the diagnosis of metastatic carcinoma in patients with a nonadrenal primary malignancy, proven by the more than 70% positive rate in this group.

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