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The usual ultrasonographic features of thyroid cancer are less frequent in small tumors that develop after a long latent period after the Chernobyl radiation release accident
Thyroid, 05/18/09

Drozd VM et al. - In a study to assess the ultrasound (US) features of papillary thyroid carcinoma in pts exposed to Chernobyl fallouts, it appears that irregular nodule margins, a usual sign of malignancy, are less useful in detecting thyroid cancers in radiation-exposed pts with tumors <10 mm. Thyroid cancers that are detected after longer latent periods display less of the US features characteristic of a malignant process, while benign US features are observed more frequently.

Methods

An analysis of US features, clinicopathological data, and latency period was performed between radiation exposure and diagnosis of cancer.
There were 94 pts who were 10.6–34.3 yrs old at the time of diagnosis and 0.1–18.0 yrs old at the time of the Chernobyl accident.

Results

Nodules >10 mm were associated with the higher frequency of irregular margins, longer period of latency, and bilateral lymph node involvement.
Irregular tumor margins correlated with shorter period of latency and unilateral nodal disease.
Hypoechoic nodules were observed more frequently in female pts, in the absence of halo or calcifications.
Hypoechogenicity correlated with the shorter latency and younger age of pts.

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