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See Latest ArticlesIncreased epicardial adipose tissue (EAT) volume in type 2 diabetes mellitus and association with metabolic syndrome and severity of coronary atherosclerosis
Clinical Endocrinology, 06/01/09
Wang CP et al. – Results show that epicardial adipose tissue (EAT) volume is increased in type 2 diabetes mellitus (T2DM) pts and is associated with unfavorable components of MetS and coronary atherosclerosis. The close anatomical relationship between EAT and the coronary arteries, combined with other evidence of EAT as a biologically active adipokine-secreting tissue, suggest that EAT participates in the pathogenesis of diabetic coronary atherosclerosis.
Methods- Hospital-based case control study of 49 pts with T2DM and 78 nondiabetic controls
- Cardiac multislice computed tomography to measure EAT volume, Gensini score, coronary artery calcium score and, coronary lesions
- Investigation of relationships between EAT volume, markers of coronary atherosclerosis and anthropometric and biochemical parameters of metabolic syndrome (MetS)
- MetS: BMI, waist circumference, fasting serum glucose, total cholesterol, HDL-cholesterol, and triglycerides levels
- EAT volume significantly higher in pts with T2DM than in nondiabetic subjects (166·1 ± 60·6 cm3 vs. 123·4 ± 41·8 cm3)
- On logistic regression analysis, independent and significant associations between EAT and diabetic status
- EAT volume significantly associated with MetS components, Gensini score, coronary lesions, coronary disease and coronary calcium scores
- Univariate, multivariate and trend analyses confirmed EAT volume association with MetS component clustering and the coronary atherosclerosis index
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