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See Latest ArticlesStathmin as a marker for malignancy in pheochromocytomas
Experimental and Clinical Endocrinology & Diabetes, 05/19/09
Björklund P et al. - In a study to assess the use of stathmin as a marker for malignancy in pheochromocytomas, stathmin protein overexpression was observed by immunohistochemistry, and distinct differential protein expression between benign and malignant/metastasis specimens was confirmed by Western blot analysis. The results introduce stathmin as a possible diagnostic marker for malignant pheochromocytomas.
Methods- A number of genetic aberrations have been described in pheochromocytomas, but no marker associated with malignancy has been reported.
- Expression microarray containing 7770 cDNA clones was applied and expression profiles in 11 tumors were analysed compared with normal adrenal medulla.
- Stathmin (STMN1, Op18) was most conspiciously overexpressed among the differentially expressed genes.
- RT-PCR analysis further confirmed mRNA overexpression, 6 to 8-fold for benign and malignant tumors, and 16-fold for metastases.
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