Endocrinology Medical News about Thyroid Cancer

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. AHA Guidelines on Cardiac CT for Assessing Coronary Artery Disease

3. Rapid correction of low vitamin D status in nursing home residents

4. 2008 Exclusive Survey—Earnings: Good news for primary care income

5. Medicare pay-for-reporting effort draws fire from frustrated doctors

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Clinical and pathological factors related to 18F-FDG-PET positivity in the diagnosis of recurrence and/or metastasis in patients with differentiated thyroid cancer
Annals of Surgical Oncology, 05/08/09

Esteva D et al. - ¹⁸F-FDG-PET study offers a high sensitivity and positive predictive value (PPV) in DTC patients with negative whole-body scan (WBS) and thyroglobulin (Tg) positive. The use of FDG-PET is strongly recommended in DTC patients with large tumors, thyroid capsule invasion or poor-prognosis variants.

Methods

Study was undertaken to:
- analyze the relationship between a positive ¹⁸F- FDG-PET result and clinical and tumor factors in pts treated for differentiated thyroid cancer (DTC) and under suspicion of recurrence or metastasis, and
- determine the diagnostic validity of PET in DTC pts with elevated serum Tg and negative ¹³¹I WBS
50 DTC pts with elevated serum Tg and negative WBS treated with total thyroidectomy and ¹³¹I ablation
Thyroxin treatment was withdrawn and pts were on iodine-free diet before WBS
Tg, anti-Tg Abs, and TSH were determined
Pts with negative WBS and elevated Tg underwent PET study 1 week later
PET findings were verified by pathology findings or other imaging techniques and/or 12-mo f/u
Relationship between PET findings and tumor and clinical variables was analyzed

Results

PET was positive in 32/39 pts with confirmed disease and negative in 7/11 of disease-free cases a PPV of 89%
Tumor size and thyroid capsular invasion were associated with positive PET study
Relationship of PET findings with Tg levels and age at diagnosis was close to significance

<< Previous
Addison’s disease and hypertransaminasemia

Next >>
Hypothyroidism secondary to hypothalamic-pituitary dysfunction...