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Carrier mediated thyroid hormone transport into placenta by placental transthyretin
Journal of Clinical Endocrinology and Metabolism, 05/08/09
Landers KA et al. - The results suggest that human placenta and choriocarcinoma cells secrete transthyretin which binds extracellular T4 and that T4 binding results in increased internalisation of TTR-T4 complex. TTR production by trophoblasts may represent a mechanism to allow transfer of maternal thyroid hormone to the fetal circulation that could have important implications for fetal development.
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