Endocrinology

Your Article Summary

See Latest Articles

Masked volume wise principal component analysis of small adrenocortical tumours in dynamic [11C]-metomidate positron emission tomography
BMC Medical Imaging , 04/23/09

Razifar P et al. – The results indicate that the definition of regions of interest (ROIs) may be more accurate and precise in Masked Volume Wise Principal Component 1 (MVW-PC1) images than in conventional summed images. This might improve the precision of PET measurements, for instance in therapy monitoring as well as for delineation of the tumour in radiation therapy planning.

• Study applies MVW-PCA to 14 dynamic 11C-metomidate-PET (MTO-PET) examinations of 7 pts with small adrenocortical tumours
• MTO-PET was performed before and 3 days after starting per oral cortisone treatment
• The whole dataset, reconstructed by filtered back projection (FBP) 0-45 minutes after the tracer injection, was used to study the tracer pharmacokinetics

• Early, intermediate and late pharmacokinetic phases could be isolated in this manner
• The MVW-PC1 images correlated well to the conventionally summed image data but the image noise in the former was considerably lower
• PET measurements performed by defining ROIs comprising 4 contiguous pixels with the highest radioactivity concn showed a trend towards higher SUVs when the ROIs were outlined in the MVW-PC1 component than in the summed images
• Time activity curves derived from "50% cut-off" ROIs based on an isocontour function showed a decrease of the SUVs in normal adrenal glands and in adrenocortical adenomas after cortisone treatment

Related Articles

See all related articles

Positron emission tomography at the end of first-line therapy and during follow-up in patients with Hodgkin lymphoma: A retrospective study
Annals of Oncology, 11/11/09    Relevance Score: 96%

Comparison of 18F-Fluoro-L-DOPA, 18F-Fluoro-Deoxyglucose, and 18F-Fluorodopamine PET and 123I-MIBG Scintigraphy in the Localization of Pheochromocytoma and Paraganglioma
Journal of Clinical Endocrinology and Metabolism, 11/12/09    Relevance Score: 93%

Evaluation of gross tumor size using CT, 18F-FDG PET, integrated 18F-FDG PET/CT and pathological analysis in non-small cell lung cancer
European Journal of Radiology, 10/26/09    Relevance Score: 92%

Hodgkin's lymphoma in remission after first-line therapy: Which patients need FDG-PET/CT for follow-up?
Annals of Oncology, 11/17/09    Relevance Score: 91%

Miscellaneous Cancers (Lung, Thyroid, Renal Cancer, Myeloma, and Neuroendocrine Tumors): Role of SPECT and PET in Imaging Bone Metastases
Seminars in Nuclear Medicine, 10/14/09    Relevance Score: 90%

Today in Adrenal Glands...keeping you current

Receive free subspecialty "5-minute updates" via email

Association of the CYP27B1 C(-1260)A Polymorphism with Autoimmune Addison's Disease
Experimental and Clinical Endocrinology & Diabetes, 12/10/09

Effectiveness of cabergoline in monotherapy and combined with ketoconazole in the management of Cushing's disease
Pituitary, 12/08/09

The Utility of Metaiodobenzylguanidine Single Photon Emission Computed Tomography/Computed Tomography (MIBG SPECT/CT) for the Diagnosis of Pheochromocytoma
Annals of Surgical Oncology, 12/08/09

 See all of Adrenal Glands

Today in Diagnostics...keeping you current

Receive free subspecialty "5-minute updates" via email

Does Normal Thyroid Gland by Ultrasonography match with Normal Serum Thyroid Hormones and Negative Thyroid Antibodies
Experimental and Clinical Endocrinology & Diabetes, 12/10/09

False Positive test Results for Pheochromocytoma from 2000 to 2008
Experimental and Clinical Endocrinology & Diabetes, 12/10/09

No survival difference after successful 131I ablation between patients with initially low-risk and high-risk differentiated thyroid cancer
European Journal of Nuclear Medicine & Molecular Imaging, 12/08/09

 See all of Diagnostics

Today in Endocrine Oncology...keeping you current

Receive free subspecialty "5-minute updates" via email

Phase III trial of chemotherapy using 5-fluorouracil and streptozotocin compared with interferon alpha for advanced carcinoid tumors: FNCLCC–FFCD 9710
Endocrine-Related Cancer, 12/10/09

Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer
Endocrine-Related Cancer, 12/09/09

Blood dosimetry from a single measurement of the whole body radioiodine retention in patients with differentiated thyroid carcinoma
Endocrine-Related Cancer, 12/09/09

 See all of Endocrine Oncology