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Thorn SR et al. - PI-IUGR is associated with reduced BCAA uptake and growth factors, yet up-regulation of proximal insulin signaling and a marked increase in the gluconeogenic pathway. Lack of activation of several energy and stress sensors in fetal liver and skeletal muscle, despite hypoxia and low energy status, suggests a novel strategy for survival in the PI-IUGR fetus, but with potential maladaptive consequences for reduced nutrient sensing and insulin sensitivity in postnatal life.


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