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See Latest ArticlesPolyhydramnios, fetal overgrowth, and macrocephaly: Prenatal ultrasound findings of Costello syndrome
American Journal of Medical Genetics, 03/16/09
Smith LP et al. - The most common prenatal findings in the literature and in this cohort were polyhydramnios and fetal overgrowth with relative macrocephaly. Based on this study, ultrasound identification of polyhydramnios in the context of prenatal overgrowth, especially with relative macrocephaly, needs to raise the possibility of a diagnosis of Costello syndrome in the fetus because of the life-threatening cardiac complications that may occur early in the newborn period.
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