Endocrinology Medical News about An Extensive Genetic Program Occurring during Postnatal Growth in Multiple Tissues

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An Extensive Genetic Program Occurring during Postnatal Growth in Multiple Tissues
Endocrinology, 12/05/08

Finkielstain GP et al. - The authors conclude that there exists an extensive genetic program occurring during postnatal life. Many of the involved genes are regulated coordinately in multiple organs, including many genes that regulate cell proliferation. At least some of these are themselves apparently regulated by growth, suggesting that, in the embryo, a gene expression pattern is established that allows for rapid somatic growth of multiple tissues but then, during postnatal life, this growth leads to negative-feedback changes in gene expression that in turn slow and eventually halt somatic growth, thus imposing a fundamental limit on adult body size.

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