Garcia-Gomez D et al. - This is a case of a 47-year-old man with an adenocarcinoma of the esophagus, who developed panhypopituitarism, diabetes insipidus, and symptoms secondary to metastatic infiltration of the hypothalamic-pituitary region. The unusual primary tumor and clinical presentation make this case very interesting. Clinical presentation, diagnosis, and therapeutic management of hypothalamic-pituitary metastases are reviewed.