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Selective Loss of MEG3 Expression and IG-DMR Hypermethylation in the MEG3/DLK1 Locus in Human Clinically Non-functioning Pituitary Adenomas
Journal of Clinical Endocrinology and Metabolism, 07/16/08

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Free Abstract

Gejman R et al. - MEG3 is the first human gene identified expressed in multiple normal human pituitary cell types with loss of expression specifically restricted to clinically non-functioning pituitary adenomas. The IG-DMR hypermethylation may be an additional mechanism for MEG3 gene silencing in such tumors.

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Corticotropin Tests for Hypothalamic-Pituitary Adrenal Insufficiency
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