Zhang H et al. - This study supports the presence in 1p36 of quantitative trait locus (QTLs) affecting bone mineral density (BMD) at multiple skeletal sites. Methods
Aim was to better characterize the genetic risk factors for low BMD located in region on 1p36
Same group of families for 1095 SNPs located across 11 Mb on 1p36 were genotyped
Linkage and LD analyses were performed using the variance component approach
Results
Two QTLs for femoral neck BMD, lumbar spine BMD and trochanter BMD were identified simultaneously on 1p36
LD analysis identified several SNPs potentially associated with BMD, including the RERE gene SNP rs11121179
Other candidate genes include G1P2, SSU72 and CCDC27
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