Larsson L et al. - Chromogranin A and B (CAB) antiserum may help identify peptide hormone-producing cells and tumors Methods
Study of an antiserum that recognizes both chromogranin A and B (CAB) to show peptide hormone-producing endocrine cells and tumors in humans
Results
Antiserum showed endocrine cells along the gastrointestinal tract, most islet cells, adrenomedullary cells, thyroid C cells, scattered endocrine cells in the respiratory tract, and numerous cells in the adenohypophysis
CAB-positive cells outnumbered those storing chromogranin A in intestines and anterior pituitary
Also CAB-positive was an array of different peptide hormone-producing tumor cells: several types of islet cell tumors; gastric, intestinal, and bronchial carcinoids; medullary thyroid carcinomas; pheochromocytomas
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