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Estrogen Elicits Dorsal Root Ganglion Axon Sprouting via a Renin-Angiotensin System
Endocrinology, 07/11/08

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Chakrabarty A et al. - The findings support the hypothesis that estrogen promotes DRG nociceptor axon sprouting by up-regulating the AT2 receptor, and that locally synthesized ANGII can induce axon formation. Therefore, estrogen may contribute to some pain syndromes by enhancing the pro-neuritogenic effects of AT2 activation by ANGII.

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