Kallio A et al. - Results suggest that the osteoblast protective anti-apoptotic effects of E2 are mediated by both ER and ER beta but those of Osp primarily by ER. In addition, E2 and Osp opposed the etoposide-induced increase of IL-6 and decrease of OPG which changes would increase osteoclastic activity. These anti-resorptive effects of E2 and Osp upon etoposide challenge differed from each other and they seemed to be differentially mediated in ER and ER beta expressing osteoblast-derived U2OS cells.
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