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Progesterone is Extensively Metabolized in Osteoblasts: Implications for Progesterone Action on Bone
Hormone and Metabolic Research, 06/09/08

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Quinkler M et al. - Progesterone is subject to extensive intracellular inactivation in human osteoblasts, with potential attenuation of local progesterone receptor responses. Conversely, osteoblasts have the capacity to convert progestogens to metabolites reported to have anabolic actions through the estrogen receptor.

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