Tamaki J et al. – Osteoporosis including prevalent vertebral fracture may be associated with carotid atherosclerosis in the first 10 years of postmenopausal women. Methods
A study to examine whether low bone mass predicts increased carotid atherosclerosis
A 10-year f/u survey of 1,040 women was conducted in 2006
609 women ≥50 yrs old in 2006 w/o a history of cv or connective tissue diseases at baseline were analyzed
BMD and evaluation of vertebral fracture at baseline were used
The intima-media thickness of carotid bifurcation (BIF-IMT) was measured by B-mode ultrasonography in 2006
Results
Adjusted BIF-IMT values of subjects with spine T-score ≥-1, between-2.5 and -1, and <-2.5 or prevalent vertebral fracture were 1.19 mm, 1.34 mm, 1.57 mm, respectively
This was in women with less than 10 yrs since menopause (YSM) (n=159), 1.30 mm, 1.32 mm, 1.53 mm, in women with YSM ≥10 w/o a history of hypertension at baseline (n=144)
Those values among no versus prevalent vertebral fracture in women with YSM ≥10 were 1.40 mm, 1.66 mm
Those associations were independent of age, BMI, total cholesterol, smoking and drinking habits, history of diabetes mellitus, and hypertension
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