Hong IS et al. - GnRH-I and -II induce apoptosis in human granulosa cells through GnRH-I receptors, which mediate the proteolytic caspase cascade involving caspase-8 (the initiator) and caspase-3 and 7 (the effectors). FSH protects human granulosa cells from apoptosis induced by GnRH-I or II. This raises potentially important roles of GnRH-I and GnRH-II in regulating follicle development and atresia together with FSH.
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