Goodwin PJ et al. – High insulin levels in locoregional breast cancer indicate insulin resistance and are associated with other components of insulin resistance syndrome (IRS); development of therapies targeting hyperinsulinemia in early stage breast cancer may be useful in long-term management of breast cancer survivors Methods
Study of possible association of hyperinsulinemia with insulin resistance in a cohort of newly diagnosed locoregional breast cancer pts and associations of hyperinsulinemia with broader IRS
Glucose, insulin, and lipid analysis in fasting blood of 504 pts with T1-3, N0-1, M0 breast cancer
Review of pt anthropomorphic measurements and diet, exercise, sleep data
Review of relationships of insulin with 3 validated indices of insulin resistance and with IRS attributes
Results
High insulin levels correlated strongly with insulin resistance calculated using 3 indices of insulin resistance/sensitivity
Hyperinsulinemia associated with other IRS components: obesity, high waist–hip ratio, lipid profile
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