Chu LW et al. - Besides the link between the 8q24 region and prostate cancer risk, population studies do not convincingly show that polymorphisms in androgen metabolism genes are associated with prostate cancer risk. Methods
A review to provide insights and direction for epidemiologic research on androgens and prostate cancer
Results
To date, data on serum androgens in prostate cancer remain inconclusive
Large studies on variants in some androgen-metabolizing genes do not show a convincing links to prostate cancer
Sufficient data is not available to draw conclusions on other genes related to androgen metabolism, and estrogen-related genes
Although there is some controversial evidence, suggesting that select variants may confer risk to certain subtypes of prostate cancer
The most notable finding in 2007 is the highly reproducible link between the chromosome 8q24 risk region and prostate cancer susceptibility
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