Cheng Long, et al. - Chronic treatment with the immunosuppressive drug rapamycin leads to hypertension; however, the mechanisms are unknown...These data demonstrate that displacement of FKBP12/12.6 from ryanodine receptors induces an endothelial intracellular Ca2+ leak and increases conventional protein kinase C–mediated endothelial NO synthase Thr495 phosphorylation leading to decreased NO production and endothelial dysfunction
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