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Degradation of STAT5 proteins in 3T3-L1 adipocytes is induced by TNF-alpha and cycloheximide in a manner independent of STAT5A activation
Endocrinology and Metabolism, 02/21/07
Print     Email This Article     Save in My Library   Free Abstract
Z. Elizabeth Floyd., et al. – Tumor necrosis factor-alpha (TNF-alpha) is a multifunctional cytokine that has been implicated as a causative factor in obesity-linked insulin resistance. It is commonly accepted that macrophage-derived TNF-alpha acts in a paracrine manner on adjacent adipocytes to inhibit the expression of various adipocyte genes and to attenuate insulin signaling

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