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Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins
Endocrinology and Metabolism, 02/21/07
Print     Email This Article     Save in My Library   Free Abstract
Carey N. Lumeng., et al. – Obesity leads to a proinflammatory state with immune responses that include infiltration of adipose tissue with macrophages. These macrophages are believed to alter insulin sensitivity in adipocytes, but the mechanisms that underlie this effect have not been characterized. We have explored the interaction between macrophages and adipocytes in the context of both indirect and direct coculture

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