Kim C. Jonas, et al. - 11-beta-Hydroxysteroid dehydrogenase (11-beta-HSD) enzymes regulate glucocorticoid availability in target tissues. 11-beta-HSD1 is the predominant isoenzyme expressed and active in human granulosa-lutein (hGL) cells. This study investigated the effects of pharmacological inhibitors of prostaglandin (PG) synthesis on 11-beta-HSD1 activities and expression in hGL cells