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Insulin resistance in women with polycystic ovary syndrome
Fertility and Sterility, 08/17/06
Andrea Dunaif M.D. - Polycystic ovary syndrome (PCOS) is associated with insulin resistance. There are also defects in pancreatic beta-cell function in affected women. These abnormalities are heritable. There are post-binding defects in insulin receptor signaling, with selective resistance to insulin's metabolic actions and constitutively activated mitogenic signaling in skeletal muscle
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