Promoter-targeted THAP7 can also recruit TAF-Iß and silencing mediator of retinoid and thyroid receptors/nuclear hormone receptor corepressor (NCoR) proteins to promoters, and knockdown of TAF-IBeta by small interfering RNA relieves THAP7-mediated repression, indicating that, like nuclear hormone receptors, THAP7 may represent a novel class of transcription factor that uses TAF-IBeta as a corepressor to maintain histones in a hypoacetylated, repressed stat
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