The Value of Immunoassays for Metanephrines in the Biochemical Diagnosis of Pheochromocytomas Unger N et al. - Measurement of metanephrines instead of catecholamines by either technique improved the diagnostic accuracy for the diagnosis of pheochromocytomas. Determination of plasma free metanephrines demonstrated a higher accuracy than their urinary counterparts. The use of immunoassays may be an alternative to the laborious HPLC, although the method needs to be evaluated in more detail. [more...]