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Lack of regulation of 11beta-hydroxysteroid dehydrogenase type 1 during short term manipulation of growth hormone in patients with hypopituitarism
Walker B et al. - GH did not regulate 11beta-HSD1 rapidly in vivo in humans. Altered cortisol metabolism with longer term changes in GH may reflect indirect effects on 11beta-HSD1. These data do not suggest that glucocorticoid replacement doses need to be increased immediately after introducing GH therapy to compensate for reduced 11beta-HSD1 activity, although dose adjustment may be required in the longer term. [more...]
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