Impact of sex steroids on neuroinflammatory processes and experimental multiple sclerosis
Kipp M et al. – A review of the impact of sex steroids on neuroinflammatory processes and experimental multiple sclerosis summarizes results of in vitro studies and experimental animal models and surveys the literature. Methods- Review of sex steroids impact on neuroinflammatory processes and experimental multiple sclerosis
Results- Synthetic and natural estrogens as well as progestins modulate neuronal development and activity
- Steroids attenuate neuroinflammation by reducing pro-inflammatory property of astrocytes
- Variable effect based on brain region and toxic condition
- Both hormones can individually mediate protection, with more effective cooperation
- Animal model for multiple sclerosis shows steroids achieve remyelination after demyelination
- Cellular mechanisms involve interactions with astroglia, insulin-like growth factor-1 responses, and recruitment of oligodendrocytes
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