TSH Receptor - Autoantibody Interactions
Smith BR et al. - Although it has been postulated that stimulating and blocking TRAbs bind to different regions on the TSHR, the authors studies showed that antibodies of both types bind well to the TSHR containing only N-terminal amino acids 22-260. Whether TRAbs make contact with other parts of the TSHR in order to produce their biological effects (stimulation or blocking) remains to be elucidated. [more...]
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